ClickGene presented results at SCNAC 2017

5 ESRs presented their project and results during the 17th Symposium on Chemistry of Nucleic Acid Components in Český Krumlov, Czech Republic. The conference included 52 oral presentations and 97 poster presentations from 5 to 7 June 2017. It was hosted by one of the ClickGene partners, the Institute of Organic Chemistry and Biochemistry AS CR.

ESRs presented the following posters:

 

ClickGene PIs and ESRs attend Symposium on Chemistry of Nucleic Acid Components

Most of the ClickGene PIs and ESRs will be attending the 17th Symposium on Chemistry of Nucleic Acid Components (SCNAC) in Český Krumlov, Czech Republic, held in June of this year. Last year’s event attracted more than 150 participants from 21 countries. The programme consists of 10 plenary lectures, 4 "Emerging young investigator" invited lectures, ca. 40 short oral presentations and a poster session.

Supervisor Michal Hocek to chair the symposium

Michal Hocek, supervisor of two ESRs for ClickGene, is the chairman of the SCNAC symposium. Michal’s main research areas include the chemistry of nucleobases, nucleosides, nucleotides and nucleic acids and his ESRs are studying in the area of genome editing and gene knockout.

Invited speakers

The list of invited speakers includes Thomas Carell of the Ludwig-Maximilians-University Munich, Germany. Thomas is, like Michal, the supervisor of two ESRs for the ClickGene project. Additionally, he is the lead of WP1 Materials for Genome Editing. Other speakers include Cynthia Burrows from the University of Utah, Kurt Vesterager Gothelf from the Interdisciplinary Nanoscience Center, Aarhus University and Andreas Marx from the University of Konstanz. The full list of plenary invited speakers is available on the SNAC website.

How to attend

The registration for the event is open and available on the SCNAC website. Due to limited capacity of the venue, the registration will be restricted to ca. 150 regular participants.

baseclick GmbH launches a new and enhanced click chemistry-based kit for detecting cell proliferation

baseclick GmbH – one of the industry partners of ClickGene – is very excited to announce their latest innovation, developed within the frame of ClickGene: a new and significantly enhanced click-chemistry based EdU “DetectPro”-Kit for the analysis of cell proliferation.

The baseclick EdU Kits provide a superior alternative to BrdU and [3H] thymidine assays by incorporating the thymidine analogue EdU during DNA synthesis and then using click chemistry for detection in a variety of dye fluorescent readouts. No harsh, DNA denaturating and laborious antibody based detection is required.

The new DetectPro Kits combine all the advantages of their very popular EdU Click Kits with a brand new fluorescence enhancer system. This makes them as easy to handle and as reliable as their predecessor, while showing outstanding efficiency and greatly enhanced signal and sensitivity. With key features such as low cell number requirement paired with low signal-to-noise ratios, baseclick  is on the forefront to the ultimate goal of “low content diagnosis”.

The new DetectPro Kits will be offered for three different readout systems: cell proliferation analysis by imaging, by flow cytometry and by high throughput screening analysis (HTS). Please visit the baseclick GmbH website for more detailed information on their new click-chemistry based tool.

 

Typical EdU cell proliferation assay: Incubation of HeLa cells for 30 minutes with EdU followed by click reaction guided detection using fluorescence microscopy. While in baseclick's standard EdU cell proliferation assay at such short exposure times (here 15 ms) only show very light signals of proliferating cells (middle image), the newly invented EdU DetectPro assay (right image) is able to detect cell proliferation with even higher efficiency and sensitivity with minimal background.

New ClickGene publication in Angewandte Chemie

ClickGene ESR Ján Matyašovský is among the authors of a new publication in Angewandte Chemie (made available as open access): 

Matyašovský, J., Perlíková, P., Malnuit, V., Pohl, R., & Hocek, M. (2016). 2-Substituted dATP Derivatives as Building Blocks for Polymerase-Catalyzed Synthesis of DNA Modified in the Minor Groove. Angewandte Chemie, 128(51), 16088-16091. http://dx.doi.org/10.1002/ange.201609007

ClickGene Mid-Term Meeting

The ClickGene Mid-Term Meeting will be held from the 29th November to the 1st December in Bologna Italy. The event will consist of three thoroughly planned days:

  • On the first day the programme network meeting will be held
  • On the second day the technical review meeting will take place
  • On the final day the ESRs will be treated to a quality management workshop presented by baseclick GmbH

The Programme Network Meeting will consist of an update of the project as a whole. The coordinator will give a short presentation on the status followed by the individual WP leaders. The next hours will be reserved for the ESRs. They will present their work progress to the consortium.

The ESRs will once again be busy during the Technical Review Meeting. The will each give a short presentation telling the consortium their background, their work and training experience in the network. They will also receive a short feedback on their presentations.

The location for the event will be the ISOF Institute and the EC Project officer and a technical expert will be present for the whole meeting.

This meeting follows the 2nd Annual Network Meeting that was held in Grenoble from the 25th to 27th of March.

Mid-Term Meeting this winter

Planning for the ClickGene Mid-Term Meeting is underway and progress is looking good. We will be hoping to avoid the freezing weather by holding it in Bologna, Italy from the 29th November to the 1st December. The participants are expected to arrive on the 28th November and the first day of work will start the next morning. On the first day the Programme Network Meeting will be held. This includes an update of the project status by the coordinator and updates on the individual Work Packages by their respective leaders. Following that Jeanette Müller will advise the attendees on the requirements, expectations and best practices. Before lunch the first ESRs (Early Stage Researchers) will give an update on their work progress – the other ESRs will do the same after lunch and in the afternoon. Later in the day there will be a Management Board meeting.

On the second day the Technical Review Meeting will take place. The morning and early afternoon will mainly be filled with individual reports by the ESRs and the coordinator. Later in the afternoon the fellows will be holding individual meetings with the REA and a reviewer to discuss their experience within the network.

The final day is reserved for a workshop held by baseclick GmbH. There will be more information available in the Training Programme in due time.

Scientific Oktoberfest with ClickGene

ClickGene will participate at the CIPSM Scientific Oktoberfest on 15–16 September 2016 in Munich. Some of the internationally most distinguished researchers in the field of Chemistry & Chemical Biology will meet there. The conference will be held at the Department of Chemistry of the Ludwig Maximilians University Munich.

→ Scientific Oktoberfest website

Confirmed keynotes:

  • Jason Chin, University of Cambridge
  • Darren Dixon, University of Oxford
  • Petra Hajkova, Imperial College London
  • Christopher Hunter, University of Cambridge
  • Kai Johnsson, École Polytechnique Fédérale de Lausanne
  • Tom Muir, Princeton University
  • Bradley L. Pentelute, MIT, Cambridge
  • Barry Sharpless, The Scripps Research Institute, La Jolla
  • Antonio Togni, ETH Zürich

 

Gianluca Toniolo wins European Young Chemists Network prize

Gianluca Toniolo has been awarded a prize from the European Young Chemists Network (EYCN) for the best overall presentation at the COST Action CM1201 meeting  in Grenoble, France recently.

Gianluca is an Early Stage Researcher funded by the European Training Network ClickGene and a PhD student under the supervision of Dr Chatgilialoglu at the Institute of Nanoscience and Nanotechnology “Demokritos”, Athens. His thesis focuses on Receptor activating polymer coated transfection agents.

The ClickGene team congratulates Gianluce on his initial research findings and the ways in which he presented these to the large audience of scientists and industry representatives.

The European Young Chemists’ Network (EYCN) is the young division of EuCheMS (European Chemical Sciences). It has been active since 2006 and its goal is to promote Chemistry in Europe, as well as to give new educational and networking opportunities to students and professionals. The EYCN was able to arrange a collaboration with the COST Action within the H2020 and could attend the meeting in Grenoble (France).

 

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