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New ClickGene ESR work published in Chemical Science

ClickGene’s ESR Sarah Walsh from ATDBio has recently published her first paper in collaboration with Prof Tom Brown and Dr Afaf El-Sagheer. Published in the Chemical Science journal, the work showed how the instability of DNA triplex can be addressed and resolved through the introduction of a thiazole orange (TO) intercalator onto a thymine nucleobase in triplex forming oligonucleotides (TFOs). By overcoming DNA triplexes’ instability, “TOTFO” probes can expand triplex applications into many areas including diagnostics and cell imaging.