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New ESR publication in Organic Letters

ClickGene’s ESR Alessandro Panattoni from IOCB has recently published, in collaboration with Prof Michal Hocek and Dr Radek Pohl, a new paper on alkyne-linked thymidine nucleotides for faster and more efficient post-synthetic modifications of DNA through CuAAC. Two new building blocks bearing long and flexible linkers between the nucleobase and the terminal alkyne were synthesized and incorporated both chemically and enzymatically into DNA. The flexibility and length of the new linkers resulted in a significant advantage for the reactivity in CuAAC and oligonucleotides bearing these alkyne tethers underwent CuAAC reactions more efficiently than the standard ethynyl- and 1,7-octadiynyl- modified oligonucleotides.