ClickGene presented results at SCNAC 2017

5 ESRs presented their project and results during the 17th Symposium on Chemistry of Nucleic Acid Components in Český Krumlov, Czech Republic. The conference included 52 oral presentations and 97 poster presentations from 5 to 7 June 2017. It was hosted by one of the ClickGene partners, the Institute of Organic Chemistry and Biochemistry AS CR.

ESRs presented the following posters:

 

baseclick GmbH launches a new and enhanced click chemistry-based kit for detecting cell proliferation

baseclick GmbH – one of the industry partners of ClickGene – is very excited to announce their latest innovation, developed within the frame of ClickGene: a new and significantly enhanced click-chemistry based EdU “DetectPro”-Kit for the analysis of cell proliferation.

The baseclick EdU Kits provide a superior alternative to BrdU and [3H] thymidine assays by incorporating the thymidine analogue EdU during DNA synthesis and then using click chemistry for detection in a variety of dye fluorescent readouts. No harsh, DNA denaturating and laborious antibody based detection is required.

The new DetectPro Kits combine all the advantages of their very popular EdU Click Kits with a brand new fluorescence enhancer system. This makes them as easy to handle and as reliable as their predecessor, while showing outstanding efficiency and greatly enhanced signal and sensitivity. With key features such as low cell number requirement paired with low signal-to-noise ratios, baseclick  is on the forefront to the ultimate goal of “low content diagnosis”.

The new DetectPro Kits will be offered for three different readout systems: cell proliferation analysis by imaging, by flow cytometry and by high throughput screening analysis (HTS). Please visit the baseclick GmbH website for more detailed information on their new click-chemistry based tool.

 

Typical EdU cell proliferation assay: Incubation of HeLa cells for 30 minutes with EdU followed by click reaction guided detection using fluorescence microscopy. While in baseclick's standard EdU cell proliferation assay at such short exposure times (here 15 ms) only show very light signals of proliferating cells (middle image), the newly invented EdU DetectPro assay (right image) is able to detect cell proliferation with even higher efficiency and sensitivity with minimal background.

New ClickGene publication in Angewandte Chemie

ClickGene ESR Ján Matyašovský is among the authors of a new publication in Angewandte Chemie (made available as open access): 

Matyašovský, J., Perlíková, P., Malnuit, V., Pohl, R., & Hocek, M. (2016). 2-Substituted dATP Derivatives as Building Blocks for Polymerase-Catalyzed Synthesis of DNA Modified in the Minor Groove. Angewandte Chemie, 128(51), 16088-16091. http://dx.doi.org/10.1002/ange.201609007

ClickGene Mid-Term Meeting

The ClickGene Mid-Term Meeting will be held from the 29th November to the 1st December in Bologna Italy. The event will consist of three thoroughly planned days:

  • On the first day the programme network meeting will be held
  • On the second day the technical review meeting will take place
  • On the final day the ESRs will be treated to a quality management workshop presented by baseclick GmbH

The Programme Network Meeting will consist of an update of the project as a whole. The coordinator will give a short presentation on the status followed by the individual WP leaders. The next hours will be reserved for the ESRs. They will present their work progress to the consortium.

The ESRs will once again be busy during the Technical Review Meeting. The will each give a short presentation telling the consortium their background, their work and training experience in the network. They will also receive a short feedback on their presentations.

The location for the event will be the ISOF Institute and the EC Project officer and a technical expert will be present for the whole meeting.

This meeting follows the 2nd Annual Network Meeting that was held in Grenoble from the 25th to 27th of March.

Scientific Oktoberfest with ClickGene

ClickGene will participate at the CIPSM Scientific Oktoberfest on 15–16 September 2016 in Munich. Some of the internationally most distinguished researchers in the field of Chemistry & Chemical Biology will meet there. The conference will be held at the Department of Chemistry of the Ludwig Maximilians University Munich.

→ Scientific Oktoberfest website

Confirmed keynotes:

  • Jason Chin, University of Cambridge
  • Darren Dixon, University of Oxford
  • Petra Hajkova, Imperial College London
  • Christopher Hunter, University of Cambridge
  • Kai Johnsson, École Polytechnique Fédérale de Lausanne
  • Tom Muir, Princeton University
  • Bradley L. Pentelute, MIT, Cambridge
  • Barry Sharpless, The Scripps Research Institute, La Jolla
  • Antonio Togni, ETH Zürich

 

Gianluca Toniolo wins European Young Chemists Network prize

Gianluca Toniolo has been awarded a prize from the European Young Chemists Network (EYCN) for the best overall presentation at the COST Action CM1201 meeting  in Grenoble, France recently.

Gianluca is an Early Stage Researcher funded by the European Training Network ClickGene and a PhD student under the supervision of Dr Chatgilialoglu at the Institute of Nanoscience and Nanotechnology “Demokritos”, Athens. His thesis focuses on Receptor activating polymer coated transfection agents.

The ClickGene team congratulates Gianluce on his initial research findings and the ways in which he presented these to the large audience of scientists and industry representatives.

The European Young Chemists’ Network (EYCN) is the young division of EuCheMS (European Chemical Sciences). It has been active since 2006 and its goal is to promote Chemistry in Europe, as well as to give new educational and networking opportunities to students and professionals. The EYCN was able to arrange a collaboration with the COST Action within the H2020 and could attend the meeting in Grenoble (France).

 

ClickGene & COST CM1201 Meeting - Carton House Ireland

The 1st Network Meeting of ClickGene was held in conjunction with an inter-working group meeting of the COST Action CM1201: Biomimetic Radical Chemistry. The COST meeting was held at Carton House Resort, Kildare, Ireland between 23rd - 25th July (2015) and provided an excellent oppertunity for ClickGene PI's and ESRs to interact and present their work to a larger EU scientific community. The COST meeting featured a range of ClickGene speakers (Dr. Carla Fererri of CNR, Bolonga is pictured) along with internationally renowned experts in the field of radical chemistry. The joint meeting proved to be very successful with a range of open exchanges between advanced and young researchers alike. A further meeting between COST CM1201 and ClickGene is planned for April 2016 and will be held in Grenoble, France. 

1st Network Meeting - DCU Ireland


The 1st Nework Meeting of ClickGene took place on July 21st (2015) at Dublin City University, Ireland and was hosted by Dr. Andrew Kellett and Dr. Niall Barron. The ITN meeting was attended by academic and industry partners (Dr. Antonio Manetto of baseclick GmbH is pictured) along with recruited ESRs. The meeting featured a series of introductions, scientific talks, and collaborative plans. The event was hosted at the National Institute for Cellular Biotechnology (NICB) located on the DCU campus where both Dr Barron and Dr Kellett's research groups' are based.

COST Action Meeting Kildare, 23-25th July 2015


The majority of academic partners are management committee members of the COST Action CM1201: Biomimetic Radical Chemistry and are involved in the “Models of DNA Damage and Consequences” and the "Bio-Inspired Synthetic Strategies" working groups. The ClickGene consortium will participate in the COST Action Chemistry Inter Working Group Meeting in Kildare, Ireland from 23-25th July 2015.

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